Living with an inhibitor can be unpredictable

Bleeds add an extra level of difficulty to daily life

	Whether you have hemophilia A or B, the development of an inhibitor adds an additional burden to daily life
	Bleeding events due to injury are often unavoidable in normal daily life
	Managing your bleed may consume the majority of your day

THE DEVELOPMENT OF AN INHIBITOR ADDS AN ADDITIONAL BURDEN TO DAILY LIFE

Are bleeds disrupting your life?

	Bleeds interfere with my schoolwork
	Bleeds can also interfere with my social life
	I’ve sometimes had to use multiple therapies to help control my bleeds

	Managing a bleed can consume the majority of my day
	A bleed can make my day come to a complete stop
	Sometimes my bleeds make me seek out my doctor to help control them

THE UNPREDICTABILITY OF TREATING A BLEED AFFECTS YOU AND YOUR LOVED ONES

How SEVENFACT works in your body

When infused, SEVENFACT activates factors in the coagulation cascade

This leads to a “thrombin burst,” which converts fibrinogen into fibrin

This “thrombin burst” reinforces the platelet plug—creating a strong, durable clot

See full Prescribing Information for details.

SEVENFACT: The first inhibitor bypassing agent approved in over 20 years

Studies of SEVENFACT showed that an initial dose of 225 mcg/kg was the optimal choice to:

Achieve peak thrombin burst for clot formation*
Control bleed quickly with fewer doses^†

*As seen in lab tests.
^†SEVENFACT 225 mcg/kg initial dose regimen (IDR) compared to SEVENFACT 75 mcg/kg IDR in the PERSEPT 1 clinical trial.

An innovative recombinant form of human Factor VIIa, SEVENFACT differs molecularly from other available bypassing agents

View instructions on how to mix SEVENFACT

WATCH VIDEO

Find additional support and resources for SEVENFACT

LEARN MORE

NEXT: Learn more about the efficacy and safety of SEVENFACT

Important Safety Information

What is the most important information I should know about SEVENFACT?

The most serious possible side effect of SEVENFACT is abnormal clotting involving blockage of blood vessels, which include stroke, blockage of the main blood vessel to the lung, and deep vein blood clots.

You should know the signs of abnormal clotting and seek medical help immediately if they occur.
Signs of clotting in places other than your site of bleeding can include new onset of swelling and pain in limbs, new onset of chest pain, shortness of breath, loss of sensation or motor power, or altered consciousness or speech.

*What is SEVENFACT?

SEVENFACT is an injectable medicine used for the treatment and control of bleeding episodes occurring in adults and adolescents 12 years of age and older with Hemophilia A or B with inhibitors.

Injecting medicines requires special training; do not attempt to self-infuse unless you have been taught how by your healthcare provider.

Who should not use SEVENFACT (coagulation factor VIIa)?

You should not use SEVENFACT if you are allergic to rabbits, or if you have known allergies to SEVENFACT or any of its components. Seek immediate medical help if you experience hives, itching, rash, difficulty breathing with cough or wheezing, swelling around the mouth and throat, tightness of the chest, dizziness or fainting, or low blood pressure after taking SEVENFACT.

Tell your healthcare provider prior to using SEVENFACT if you have begun treatment of a bleeding episode with another bypassing agent.

What should I tell my healthcare provider before I use SEVENFACT?

Tell your healthcare provider if you are pregnant, are nursing, or plan to become pregnant; if you have had prior blood clots, heart disease or heart failure, abnormal heart rhythms, prior pulmonary clots, or heart surgery; or if you have or have had any other medical conditions.

What are the possible side effects of SEVENFACT?

The most common adverse reactions for SEVENFACT are headache, dizziness, infusion-site discomfort, infusion-site hematoma, and infusion-related reaction and fever.

Seek immediate medical help if you have signs of a blood clot or an allergic reaction.

To report SUSPECTED ADVERSE REACTIONS or product complaints, contact HEMA Biologics at 1-855-718-4362. You may also report SUSPECTED ADVERSE REACTIONS to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

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